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Most recently, a 2026 paper in Cell Reports (PMID 41543936) implicated NNMT in tubular senescence and fibrosis in early chronic kidney disease and found selective inhibition protective in senescent kidney cells, organoids and in vivo

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GHK's high copper-binding affinity is proposed to blunt this reactivity when copper is complexed, but that is a chemistry-based rationale, not a substitute for dedicated safety data